Alzheimer’s disease and Shilajit

Alzheimer’s disease is a progressive brain disorder that causes problems with memory, behavior, and thinking. This disease is characterized by a decrease in memory, performance, and the development of dementia. It happens as a result of progressive atrophy of brain cells.
The cause of the disease has not yet been determined. It is only clear that the progressive atrophy of brain cells and their degeneration can not be explained by slowly increasing age-related changes in the type of cerebral atherosclerosis. However, if not by direct, then by indirect clinical and pathologic-anatomical manifestations (rapid development of the disease, foci of brain damage, etc.), it can be assumed that it is based on the defeat of nerve cells by viruses. According to statistics, 90% of people are carriers of viruses, and the frequent localization of viruses in nerve cells suggests that viruses can come out of a dormant state under the influence of both progressive intoxication and the growth of diseases that reduce the immune system. Medications are used for some improvement in Alzheimer’s disease. But based on the molecular composition of the shilajit, some researchers believe it can prevent or slow down the progression of Alzheimer’s disease.

Currently, modern therapeutic strategies are aimed at natural phytocomplexes and polyphenolic compounds that can either inhibit the formation of Tau filaments or disaggregate them. In particular, shilajit are used to prevent Alzheimer’s disease. However, only a few polyphenol molecules have appeared to prevent Tau aggregation, and natural drugs targeting Tau have not yet been approved. Fulvic acid, a humic substance, has a number of nutraceutical properties with potential activity to protect against cognitive impairment.

Alzheimer’s disease is a neurodegenerative disease involving extracellular plaques (amyloid-β) and intracellular tangles of the Tau protein. Recently, cluster formation has been identified as a major event involved in a neurodegenerative process caused by the conversion of either soluble peptides or oligomers into insoluble fibers. Currently, modern therapeutic strategies are aimed at natural phytocomplexes and polyphenolic compounds that can either inhibit the formation of Tau filaments or disaggregate them. However, only a few polyphenol molecules have appeared to prevent Tau aggregation, and natural drugs targeting Tau have not yet been approved. Fulvic acid, a humic substance that has several nutraceutical properties with potential activity to protect cognitive impairment.Thus, fulvic acid is likely to provide new insights into the development of potential treatments for Alzheimer’s disease using natural products.

Useful properties of Shilajit in Alzheimer’s disease-contributes to the health of the human brain.

It seems that the Shilajit has a targeted mechanism for protecting brain cells. Initial studies have shown that it has «distinct and pronounced neuroprotective activity». In 2013, a study was conducted by the center for physiological research at the Kerman University of medical Sciences in Iran. The effect of Shilajit on risk factors after traumatic brain injury was studied thoroughly. The researchers found that it had a positive effect on the three most significant factors of death after traumatic brain injury. These are brain edema, blood-brain barrier permeability, and intracranial pressure.

This incredible nutrient may also represent a new treatment option for patients suffering from mild forms of Alzheimer’s disease. The presence of fulvic acid and the treatment protocol, including the administration of complex B vitamins, have shown promising results in experimental studies.
In addition, Shilajit exhibits antiepileptic properties and potentially antipsychotic effects. Since it regulates the levels of GABA (a natural acid in the brain) to normal.

The primary component of Shilajit is an antioxidant known as fulvic acid. This powerful antioxidant promotes cognitive health by preventing the accumulation of Tau protein. Tau proteins are an important part of the nervous system, but their accumulation can cause damage to brain cells.

Researchers believe that the fulvic acid in Shilajit can stop the abnormal build-up of Tau protein and reduce inflammation, potentially improving Alzheimer’s symptoms. However, additional research and clinical trials are required to use Shilajit for the prevention of Alzheimer’s disease.

Shilajit consists mainly of humic substances, including fulvic acid, which accounts for about 60-80% of the total number of nutraceutical compounds plus some oligoelements, including selenium, which has anti-aging properties. Humic substances are the result of the decomposition of organic matter, mainly plant substances, which is the result of the action of many microorganisms. The components are divided into humins, humic acids, and fulvic acids depending on their solubility in water at different pH levels. Humins are not soluble in water under any pH conditions. Humic acid is soluble in water under alkaline conditions and has a molecular weight of 5-10 KDA. Fulvic acid is soluble in water under various pH conditions, and due to its low molecular weight (about 2 KDA), it is well absorbed in the intestine and excreted from the body within a few hours. It is likely that the medicinal properties attributed to Shilajit are provided by the significant levels of fulvic acids that Shilajit contains, taking into account that fulvic acid is known for its strong antioxidant actions and probably has systemic effects as a complement activator. Recent studies of the composition of the Andean Shilajit in Chile have shown that the ORAC index is between 50 and 500 Trolox units / g of material, which is significantly higher than that of Noni and blueberries (Quinteros et al., unpublished data). In this context, Shilajit appears to be a powerful antioxidant phytocomplex.

Shilajit, its main components and potential applications are based on the properties of fulvic acid. This phytocomplex, known as Shilajit, is mainly composed of humic substances. One of them, fulvic acid, is known for its properties, such as an antioxidant, anti-inflammatory, and memory booster. The latest research shows that humic acids are an antiplatelet factor from a Tau protein in vitro that projects fulvic acids as a potential anti-Alzheimer’s disease molecule.

Shilajit is an important, well-known component of Ayurvedic medicine, given its characteristics as Rasayana (Ayurvedic direction based on the rejuvenating properties of certain natural resources, including Shilajit), it can be especially useful in the prevention of Alzheimer’s disease. In this context, it is credited with health benefits such as increasing life expectancy, rejuvenation, and the cessation of aging. Traditionally, mumiyo is consumed by residents of Nepal and Northern India, and children usually eat it with milk for breakfast. Sherpas (people living in Eastern Nepal) claim that Shilajit is a part of their diet; they make up a population of strong men with a very high level of healthy longevity.  Ongoing research has found evidence of the high activity of the Andean form of Shilajit in improving cognitive disorders and as a stimulant of cognitive activity in humans.

Accounting the actions of fulvic acid in preventing Tau self-aggregation into pathological filaments, this compound appears to be of interest for the prevention of Alzheimer’s disease. Other common traditional applications include its action in urogenital disorders, digestive disorders, nervous disorders, and chronic bronchitis. In India, it has been stated that it is used as a yogavaha, that is, as a synergistic enhancer of other drugs. Organic components of Shilajit play also a role in transport of various mineral substances to their cellular targets.

Preclinical studies of Shilajit indicate its great potential for use in certain diseases, and various properties have been attributed, including anti-carcinogenic properties; antioxidant properties; cognitive and memory enhancers; antidiabetic properties; anxiolytic; anti-allergic properties and immunomodulator; anti-inflammatory; analgesic; antifungal properties; ability to positively interact with other drugs; protective properties at high altitudes; neuroprotective agent against cognitive disorders. Unfortunately, Shilajit does not have systematic documentation and well-established clinical studies of its antioxidant and immunomodulatory effects on humans, and it is expected that, given the reported benefits confirmed by trials, they will be available in the near future.

There are already several patents protecting the use of Shilajit in India and Nepal, such as USA patent 5,405,613-vitamin and mineral composition; USA patent No. 20030198695-Herbo-mineral composition; USA patent No. 6,440,436-method for obtaining a purified composition of Shilajit from native Shilajit; USA patent No. 6,558,712-delivery system for pharmaceutical, food and cosmetic ingredients. Another recent patent for a phytocomplex with added vitamins is WO 2011/041920.

Shilajit has a stable position as a Rasayana because of its superiority, well known in Eastern culture, and is now being introduced to the Western world with great interest. The vast majority of published works on this topic come from India, leaving this country with the status of an expert in this field of research of our planet, since it is a product that is mined, sold and researched in these latitudes. However, such a situation creates a segmentation of Shilajit, reducing it only to what has always been assumed: a natural product that is part of natural alternative medicine, and not the result of medical and biotechnological innovations around the world. Given this, it is necessary for Shilajit to break the cultural paradigm and penetrate the rest of the world through thorough research at the molecular and cellular levels that could shed light on the interaction of the active ingredients of various Shilajit preparations with biomolecules. This will make it easier for us to understand the mechanisms of their action.

In the prevention of Alzheimer’s disease, symptomatic agents (sedatives, sleeping pills), vitamins and phosphatidylserine are used to improve the transmission of nerve impulses. Assuming the viral basis of the disease, it is necessary first of all to use antiviral agents until the disease has gone far. At the same time, it is extremely important to use obviously safe, natural means. A few years ago, a clinical method was able to identify similar properties in the flowers and roots of meadowsweet. Tincture of meadowsweet several times accelerates the treatment of various viral diseases — shingles, flu, labial herpes, etc. the flowers of this marsh plant have long been used as tea and, therefore, have no contraindications. The course of treatment is long, at least 2 months, and it is carried out more than once.

The second direction in the treatment of this disease is to stimulate the regenerative abilities of the affected brain cells and their regeneration. For this purpose, you can use first Shilajit, and then propolis, conducting several consecutive cycles. To stimulate the endocrine system, licorice root is used, which has hormone-like properties. Important and application of biostimulators type phosphatidylserine that improves the transmission of nerve impulses. By the way, such substances are found in beans and cabbage. It is necessary to include in the diet as many vegetables and fruits in raw form, and in addition, vitamins in pure form, especially A, B and C. it is useful to eat honey with lemon more often. For detoxification, resort to cleansing enemas. At least 10 minutes a day should be given to therapeutic gymnastics and kneading muscle massage.

Herbal medicine with Shilajit for Alzheimer’s disease

Recently, doctors have agreed that medicinal herbs and herbal remedies can be used as General tonics in the early stages of Alzheimer’s disease. After all, many medicines that are used in traditional medicine are made on the basis of natural ingredients.

1. Articles from International Journal of Alzheimer's Disease are provided here of Hindawi Limited
2. Cornejo A, Jiménez JM, Caballero L, Melo F, Maccioni RB. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with alzheimer's disease. Journal of Alzheimer's Disease. 2011;27(1):143–153. [ PubMed] [Google Scholar]
3. Origin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296184/
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